Web1 Dec 2015 · TFF2 is upregulated in diverse pathological conditions of the GI tract. To our knowledge, no genetic or epigenetic alterations are currently known to back up a tumor supressor role for TFF2 (73). TFF3 is upregulated by inflammatory and ulcerative conditions. WebTrefoil factor 2 (Tff2) is a small, secreted protein expressed in gastrointestinal mucosa where it functions to protect and repair mucosa. It is, however, also expressed at low levels in splenic immune cells, where its role has been unclear. Tff2 is epigenetically silenced in gastric cancer and thus has been postulated to protect against cancer
Trefoil Factor 2 Regulates Proliferation and Apoptosis of …
Web15 Nov 2024 · TFF2 is a small, secreted protein, expressed in gastrointestinal mucosa where it functions to protect and repair mucosa. TFF2 is also expressed at low levels in splenic immune cells and is now... WebProteintech Anti-TFF2 Monoclonal (2D7B1), Catalog # 66471-1-IG. Tested in Western Blot (WB) applications. This antibody reacts with Human, Porcine, Rat samples. ... A downregulation of SP expression is associated with primary gastric cancer, and a progressive loss of this protein is likely to be involved in the early stage of the multi-step ... hot wheels mini camera
Genomic single nucleotide polymorphisms in the offspring of …
Web1 Jan 2013 · TFF2 reportedly plays a role in antiapoptosis, migration, proliferation, and immune modulation in gastric cancer cells, colon carcinoma cells, breast cancer cells, and bronchial epithelial cells (11– 16). TFF2 is thought to exert its biological activity through a cell surface receptor, but the receptor-mediated signals that are involved remain unclear. Web28 Mar 2024 · Gastric cancer (GC), is a cancer developing from the inner lining of the stomach .The most common cause is infection by the bacterium Helicobacter pylori,which accounts for 60% of cases. ... TFF2, and TFF3) that are widely expressed in a tissue-specific manner in the gastro- intestinal tract. Trefoil factor family 3 (TFF3) is expressed in the ... Web1 Apr 2024 · TFF2 demonstrates divergent roles in cancer biology with significant implications on cellular proliferation, apoptosis, cell invasion and migration. In particular, TFF2 exerts anti-apoptotic effects and stimulates migration of BC cells [ 100 ] and … hot wheels mini cooper 2023