Involvment of the host dna-repair enzyme tdp2
Web1 jan. 2024 · As a recently discovered DNA repair enzyme, tyrosyl-DNA phosphodiesterase 2 (TDP2) can specifically repair topoisomerase 2 (TOP2)-mediated DNA damage, … Web8 sep. 2014 · Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses. Significance …
Involvment of the host dna-repair enzyme tdp2
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WebTDP2 depletion in human cells significantly slowed the conversion of RC-DNA to cccDNA. Ectopic TDP2 expression in the same cells restored faster conversion kinetics. These … Web1 jul. 2014 · TDP1 and TDP2 were discovered and named based on the fact they process 3′- and 5′-DNA ends by excising irreversible protein tyrosyl-DNA complexes involving topoisomerases I and II, respectively. Yet, both enzymes have an extended spectrum of activities. TDP1 not only excises trapped topoisomerases I (Top1 in the nucleus and …
Web29 okt. 2024 · Koniger C, Wingert I, Marsmann M, et al. Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses. Proc Natl Acad Sci U S A. 2014; 111 (40):E4244–E4253. doi: 10.1073/pnas.1409986111 [PMC free article] [Google Scholar] WebDownload scientific diagram TDP2-mediated release of P protein from RC-DNA is caused by specific phosphotyrosyl bond cleavage. (A) Assay principle. Viral DNA with 5′-phosphorylated minus ...
WebIts conversion, upon infection, into cccDNA requires multiple poorly understood steps, including polymerase removal. We found that the host enzyme tyrosyl-DNA … Webnant TDP2 can cleave the protein–RNA linkage generated by different picornaviruses without impairing the integrity of viral RNA. Our results reveal a unique RNA repair-like function for TDP2 and suggest an unusual role in host–pathogen interactions for this cellular enzyme. On the basis of the identification of TDP2 as a potential ...
WebInvolvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses. Königer C et al. Proceedings of the National Academy of Sciences of the United States of America. 2014 Oct 07; 111(40):E4244-53
WebInvolvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses. Proc Natl Acad Sci U S A. 2014; 111: ... Involvement of host cellular multivesicular body functions in hepatitis B virus budding. Proc Natl Acad Sci U S A. 2007; 104: 10205-10210. Crossref; PubMed; higley knight helmetWeb28 apr. 2014 · TDP2 can repair this damage by cleaving the TOP2-DNA linkage. The absence of TDP2 can result in DNA damage that can affect the transcription and gene expression necessary for normal brain function ... small town wikiWeb1 jul. 2024 · It is reported that TDP2 alone does not remove TOP2-DNA complexes from genomic DNA in vitro and in cells and that depletion of TDP1 in cells does not slow the removal of Topoisomerase II complexes. DNA topoisomerase II (TOP2) activity involves a normally transient double-strand break intermediate in which the enzyme is coupled to … small town weekend getaways in texasWeb1 okt. 2014 · Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses. Select any … higley manor hoaWeb8 sep. 2014 · These data strongly suggest that TDP2 is a first, although likely not the only, host DNA-repair factor involved in HBV cccDNA biogenesis. In addition to establishing a … small town white christmas vacationWeb11 mei 2016 · Tyrosyl-DNA phosphodiesterase 2 (TDP2) is among the most recently identified DNA repair enzymes. 1,2 It excises topoisomerase II (Top2α and/or β) from the 5′-end of Top2-induced DNA breaks, which are trapped and generate the cytotoxic lesions of anticancer Top2 inhibitors.Persistent Top2 cleavage complexes are also produced by … higley landscaping waterford cthttp://sro.sussex.ac.uk/id/eprint/2554/1/TDP2_TTRAP_revised_manuscript_Nov_2010.pdf small town welcome signs