Glutamine promotes antibiotic uptake to kill

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WebMar 14, 2024 · Metabolic modulation plays a role in immune response against bacterial pathogens (17–19). Several lines of evidence have shown that metabolites, such as linoleic acid, leucine, N-acetylglucosamine, glucose, malic acid, palmitic acid, and glycine, increase hosts’ survival of Vibrio alginolyticus, Streptococcus iniae, and E. tardainfection (20–27). WebMay 2, 2024 · Therefore, the authors hypothesize that exogenous amino acids enhance cell membrane permeability allowing greater antibiotic uptake. The authors first identified notable differences in the metablites between antibiotic-sensitve (E. coli-S) and multidrug-resistant (E. coli-R) E. coli strains isolated from patients suffering from urinary tract ...

Glutathione metabolism in Cryptocaryon irritans involved in …

WebGlutamine promotes inosine biosynthesis to potentiate cell killing by AMP. (A) Percent survival of glnQ, glnP, glnH, and E. coli K12 in the presence or absence of 20 mM glutamine plus AMP... WebGlutamine-potentiated ampicillin-mediated killing was effective against biofilms of these bacteria in a mouse urinary tract infection model and against systemic infection caused … flanshaw crescent wakefield

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WebCombining the metabolites glutamine or inosine with ampicillin (AMP) could represent a new therapeutic approach to antimicrobial resistance that also avoids the development of … WebAug 21, 1992 · The synthesis of large numbers of antibiotics over the past three decades has caused complacency about the threat of bacterial resistance. Bacteria have become resistant to antimicrobial agents as a result of chromosomal changes or the exchange of genetic material via plasmids and transposons. Streptococcus pneumoniae, … WebSep 13, 2024 · Glutamine promotes antibiotic uptake to kill multidrug-resistant uropathogenic bacteria. Xian-Liang Zhao; Zhuang-gui Chen; Tian-Ci Yang; Ming Jiang; Jie Wang; Zhi-Xue Cheng; Man-Jun Yang; ... Succinate Promotes Phagocytosis of Monocytes/Macrophages in Teleost Fish. Dai-Xiao Yang; Hao Yang; Yun-Chao Cao; … can single user tally on multiple computers

Glutamine opens the "door" for ampicillin - Runhang Shu 舒润航

Xian-Liang Zhao

Web40 minutes ago · In addition to intrinsic genomic and nongenomic alterations, tumor progression is also dependent on the tumor microenvironment (TME, mainly composed of the extracellular matrix (ECM), secreted factors, and bystander immune and stromal cells). In chronic lymphocytic leukemia (CLL), B cells have a defect in cell death; contact with … WebAug 15, 2024 · Bacterial metabolism is related to resistance and susceptibility to antibiotics. Fumarate and nitrate reduction regulatory protein (FNR) is a global transcriptional regulator that regulates metabolism. However, the role of FNR in antibiotic resistance is elusive. Here, fnr deletion mutant was constructed and used to test the role in Edwardsiella tarda … can single women have ivf on nhsWebOriginal article. Zhao, X.-L. et al. Glutamine promotes antibiotic uptake to kill multidrug-resistant uropathogenic bacteria. Sci. Transl. Med. 13, eabj0716 (2024) Article CAS … flanshaw first

"WebExogenous glutamine stimulated influx of ampicillin, leading to the accumulation of intracellular antibiotic concentrations that exceeded the amount tolerated by the multidrug-resistant bacteria. Furthermore, we demonstrated that exogenous glutamine promoted … " - Glutamine promotes antibiotic uptake to kill

Glutamine promotes antibiotic uptake to kill

Exogenous alanine and/or glucose plus kanamycin kills antibiotic ...

WebIntroductionGentamicin is a conventional antibiotic in clinic. However, with the wide use of antibiotics, gentamicin-resistant Escherichia coli (E. coli) is an ever-increasing problem … WebOct 1, 2024 · Glutamine promotes antibiotic uptake to kill multidrug-resistant uropathogenic bacteria. Sci. Transl. Med. (2024) X. Liu et al. Differential antibody responses to outer membrane proteins contribute to differential immune protections between live and inactivated Vibrio parahemolyticus.

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WebJun 27, 2024 · The approach has resulted in the identification of several metabolites including glucose, alanine, pyruvate, and glutamine/inosine as crucial biomarkers that elevate antibiotic uptake to promote the antibiotic-mediated killing (Peng et al., 2015a; Su et al., 2024; Zhang et al., 2024; Li et al., 2024; Zhao et al., 2024). During the ... WebJul 10, 2024 · The overuse or abuse of antimicrobial drugs in aquaculture, aggravates the generation of drug-resistant bacteria, which has caused potential risks to human health and the aquaculture industry. Flavonoid–antibiotic combinations have been shown to suppress the emergence of resistance in bacteria, and sometimes even reverse it. Here, …

WebGlutamine promotes antibiotic uptake to kill multidrug-resistant uropathogenic bacteria. ... 2024: L-aspartic acid promotes fish survival against Vibrio alginolyticus infection through nitric oxide-induced phagocytosis. Q Gong, D Yang, M Jiang, J Zheng, B Peng. Fish & shellfish immunology 97, 359-366, 2024. 31: 2024: WebGlutamine promotes antibiotic uptake to kill multidrug-resistant uropathogenic bacteria. Xiangyang Zhao, Zhuang-gui Chen, +9 authors Xuan-xian Peng; Biology, Medicine. ...

WebOct 15, 2024 · According to the recommendation of EUCAST [ 18 ], the minimum inhibitory concentration (MIC) value of Fe 3+ ions combined with six types of antibiotics (gentamicin, chloramphenicol, ampicillin, ceftazidime, clindamycin, erythromycin) for E. coli K12 BW25113 were assessed, respectively. WebTake glutamine oral powder with a meal or snack unless directed otherwise. Take glutamine tablets on an empty stomach, at least 1 hour before or 2 hours after a meal. …

WebGlutamine potentiates the antibiotics effect of ampicillin against biofilms caused by E. coli, P. aeruginosa, A. baumannii, or K. peneumoniae in a mouse...

WebDec 1, 2024 · Exogenous glutamine potentiated gentamicin-mediated killing efficacy in glutamine and gentamicin dose-and time-dependent manners in K12-R GEN . Further experiments showed that... can single-use plastic be recycledWebJul 1, 2015 · Glutamine promotes antibiotic uptake to kill multidrug-resistant uropathogenic bacteria. Science Translational Medicine 2024 Journal article DOI: 10.1126/scitranslmed.abj0716 EID: 2-s2.0-85122024769. Part of … can sing looking for a job in los angelesWebMechanistically, the potentiation is achieved comprehensively by heat shock-enhanced proton motive force that thus promotes the bacterial uptake of aminoglycosides, as well as by increasing irreversible protein aggregation and reactive oxygen species that further augment the downstream lethality of aminoglycosides. flanshaw business parkWebBenzydamine potentiates doxycycline activity in both drug-susceptible and -resistant bacteria. We first evaluated the synergistic activity of benzydamine with eight classes of … can single use cameras be refilledWebGlutamine promotes antibiotic uptake to kill multidrug-resistant uropathogenic bacteria Xian-liang Zhao et al. DOI: 10.1126/scitranslmed.abj0716 Your name Please enter your … flanshaw avenue wakefield can single women adopt childrenWebFeb 1, 2015 · Glutamine promotes antibiotic uptake to kill multidrug-resistant uropathogenic bacteria. Zhao XL, Chen ZG, Yang TC, Jiang M, Wang J, Cheng ZX, Yang MJ, Zhu JX, Zhang TT, Li H, Peng B, Peng XX. Sci Transl Med, 13(625):eabj0716, 22 Dec 2024 Cited by: 5 articles PMID: 34936385 can sing mae hen wlad fy nhadau